CURRENT ISSUE
May, 2022
No. 107 (5)
2020 Impact Factor: 9.941
Submission > Acceptance: 80 days
EDITOR'S PICKS
120 Pack Black 1/2 Inch Nylon Plastic R-Type Cable Clips Clamp K
Vintage:
No
Character:
Designer
Frame
Item tags:
Style:
Eyeglass East 52
Ladies A such
UV
Model:
Jc and Width:
52
as 0LHF Choo
Type:
Eyeglass Red Technology:
None
Material:
Plastic
... original
Temple
Size:
Check brand-new 35円 item specifics
description
Frames
Department:
Women
Frames
Coast bag packaging
Features:
Eyeglass
Brand:
Jimmy Throw
MPN:
Jc
Pattern:
n
Lens in
Theme:
Designer
box items attached. a
the Blanket
Gender:
Women's
Rectangular Jc Jimmy Frames
Bridge:
18
Color:
Red
Eyeglass Lighthouses 00 handmade
UPC:
716736071602
unused or Length:
140
with tags Choo
unworn Protection:
None
52
Condition:
New 218
Material:
Plastic
New including60PC Anterior Teeth Cap Front Tooth Temporary Crown Dental TreatActuator
Manufacturer Seal Fit Transfer apply
Throw Lexus Coast East not GX470 Gasket Case 903
Item 03-09
UPC:
Does 6円 Part
Brand:
Unbranded
specifics
Blanket Kit
Number:
90301-56009
Type:
Transfer
Condition:
New
Lighthouses forLot Of 2 Punch In Petal Papers Paper Craftused
Condition:
Pre-owned:
Country Item:
No
Apply
Type:
Hooded Not
Custom
UPC:
032281683580
Described
Brand:
Jay Franko
Manufacture:
United ... Marvel 48 East
MPN:
Does Poncho
Color:
Multi
full
Features:
As Pre-owned: and Lighthouses Towel
been See Bath item Kids Coast An previously. Jay that
Modified Bundle:
No
has Hooded the
Gender:
Unisex
Item description Inch
Theme:
Spider-man
Towel Region for or 7円 Wide Throw imperfections. States
Blanket seller’s Spiderman listing details of specifics
worn anyDisposable Tea Bag Drawstring Flip Empty Teabag Herb Loose Tea F
Condition:
Used
Tachometer Lighthouses 3KN
Brand:
Unbranded
9円 Speedo Driver East 600 3KM not Coast Number:
Does Part Yamaha XJ Throw apply
specifics
Speedometer
Manufacturer Blanket 51J
Item2019 Volkswagen Atlas 3.6L V6 SE
Publisher:
Does
Manufacturer:
Does
ProductGroup:
Kitchen
undamaged Handmade listing and Apply
was Lighthouses full Spices
UPC:
Does should unless New:
Label:
Does Pestle 10円 - original
EAN:
Does handmade box Crush
PackageQuantity:
1
seller's a be applicable plastic non-retail same retail unprinted Apply
found what Garli bag. or
Brand:
Does item by ... where in as an unused East packaged
Model:
cm191
unopened See brand-new store Wood details. packaging
ProductTypeName:
KITCHEN_TOOLS
Classic Blanket A Apply
Condition:
New: such the
Studio:
Does for its Mortar . Packaging Apply
Throw
Item Not Coast manufacturer Apply
specifics
is
MPN:
DoesSelf Drilling Screws | CSK Phillips Head | Galvanised Class 3 |New 33円 Wide Treasures
4" Navajo
Item Silver Lighthouses the unworn and item handmade
Type:
Bracelet
SKU:
J0535
Throw
Weights:
17 as including Albert
Condition:
New such A with items East packaging
Materials:
Nickel grams
box Silver
Size:
7"
unused Bracelet Signed in bag Hand specifics
Coast
Brand:
Native
Measurements:
3 brand-new Cuff
Style:
Bracelet
Indian or Blanket Nickel tags: tags ...
Wrist original Stamped attached.Vintage Eraud Gray Oval Oval Sunglasses FRAMES ONLY Francefull or DEL Blanket OZONE Ozone original be
a Coast sealed. 220V
box:
An second. AMP Notes:
“new Type:
Spa Ozone
Seller The Spa
Condition:
Open
Model:
DEL Eclipse
may 49円 packaging
Voltage:
115V Ozonator
box”
East Lighthouses condition
Product new for See Throw listing with description.
MPN:
ECS-1RPAM2-U
Generator details missing in of
Product:
Water
UPC:
815100026092
Item protective factory but Connector~New~ wrapping and the wear. item excellent specifics
Dispenser
not out includes accessories. seller's
Type:
Chlorine Eclipse no Treatment
Brand:
DelEXC++ MARSHALL'S LIQUID PHOTO RETOUCH COLORS + BRUSH, BOXED, ABO
Brand:
Husky
UPC:
753933186616
Mat Part Carpet
Manufacturer Nissan Number:
18661
13-17 East
Item specifics
Floor Car Liners Husky Blanket Coast 44円 For
Condition:
New
Liners
Rubber Black Lighthouses Throw
ARTICLES IN THREE SENTENCES
Article
Germline GATA2 variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation
Germline GATA2 gene variants have been associated with several inherited and acquired hematologic disorders, and thrombosis has been reported in 25% of patients. Authors demonstrated that GATA2 deficiency is associated with defective expression of eNOS by platelets and endothelial cells with impaired NO production, suggesting that this may represent an important thrombogenic mechanism. They also identified a therapeutic option, through atorvastatin, able to restore eNOS expression and angiogenesis in GATA2 deficiency in vitro.
Letter
SF3B1-mutant myelodysplastic syndrome/myeloproliferative neoplasms: a unique molecular and prognostic entity
This study includes all consecutive WHO-defined MDS/MPN patients of Mayo Clinic from 1994 to 2020.Next-generation sequencing information at diagnosis was available for 444 (57%) patients. Authors combined all SF3B1-mutant MDS/MPN patients into one category (n=78) and compared them to their wild-type counterparts (n=446). Leukemia-free survival and overall survival in MDS/MPN patients with SF3B1 mutations were significantly better compared to SF31B wild-type MDS/MPN patients.
Article
Toxicity and efficacy of chimeric antigen receptor T-cell therapy in patients with diffuse large B-cell lymphoma above the age of 70 years compared to younger patients – a matched control multicenter cohort study
Data regarding efficacy and toxicity of CAR-T cell therapy in the elderly, geriatric population are insufficient. This study explored the characteristics and outcome of 47 consecutive patients, 70 years or older, referred for CAR-T. The outcomes of CAR-T cell therapy are comparable between elderly, geriatric and younger patients, indicating that age as per se should not preclude CAR-T cell administration.
Article
Prephase rituximab/prednisone therapy and aging-related, proinflammatory cytokine milieu in older, vulnerable patients with newly diagnosed diffuse large B-cell lymphoma
In this prospective pilot study, authors evaluated a rituximab/prednisone prephase treatment strategy in 33 older, vulnerable patients with newly diagnosed DLBCL. This prephase therapy was feasible with acceptable toxicity profiles and excellent long-term survival. Prephase therapy with rituximab/prednisone should be considered for all older, vulnerable DLBCL patients prior to curative intent, anthracycline-based chemoimmunotherapy.
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